N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636 - Names and Identifiers
N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636 - Physico-chemical Properties
Molecular Formula | C16H16N2OS
|
Molar Mass | 284.38 |
Solubility | DMSO: ≥20mg/mL |
Appearance | powder |
Color | peach to light tan |
Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
In vitro study | In live cells, CK-636 inhibited the Arp2/3 complex-mediated actin polymerization, and in infected SKOV3 cells, CK-63 reduced actin filament formation. CK-636 inhibition of the formation of the leading edge of the migrating T cells, causing the migration rate to slow down. In addition, most of the T cells treated by CK-636 will turn around when passing the typeface test experiment and then fall into the Z-shaped interface. The Arp2/3 complex-mediated actin polymerization was inhibited by CK-636 in living cells and reduced by CK-63 in infected SKOV3 cells. CK-636 inhibition of the formation of the leading edge of the migrating T cells, causing the migration rate to slow down. In addition, most of the T cells treated by CK-636 will turn around when passing the typeface test experiment and then fall into the Z-shaped interface. |
N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636 - Risk and Safety
Hazard Symbols | Xn - Harmful
|
Risk Codes | 22 - Harmful if swallowed
|
WGK Germany | 3 |
N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 3.516 ml | 17.582 ml | 35.164 ml |
5 mM | 0.703 ml | 3.516 ml | 7.033 ml |
10 mM | 0.352 ml | 1.758 ml | 3.516 ml |
5 mM | 0.07 ml | 0.352 ml | 0.703 ml |
Last Update:2024-01-02 23:10:35
N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636 - Introduction
CK-636 is an organic compound with the chemical name of 2-(N-cyclopropyl-N-methylamino) acetic acid, which belongs to Amine Derivatives. It is a white crystalline solid, stable at room temperature and pressure.
CK-636 are widely used in the field of scientific research, mainly for the preparation of drugs, pesticides and dyes and other compounds. It is an intermediate of organic synthesis and can be used to synthesize various organic compounds with high reactivity and selectivity.
The method for preparing the CK-636 can employ the reaction of 2-aminoethanol with cyclopropylmethylamine to obtain the product. The specific operating conditions need to be adjusted according to the experimental design, and the commonly used solvents are ethanol, ether, chloroform and so on.
When using the CK-636, you need to pay attention to some safety matters. It is a chemical substance with certain toxicity and irritation. Wear appropriate protective equipment such as gloves, goggles and lab coats during operation. Avoid contact with skin and eyes and maintain good ventilation. If ingestion or contact with the skin, should immediately rinse with plenty of water, and medical treatment.
Last Update:2024-04-09 19:05:02